From synapse to sensation: the role of circTulp4.
Trends Neurosci
; 47(9): 665-666, 2024 Sep.
Article
em En
| MEDLINE
| ID: mdl-39191629
ABSTRACT
Recent work by Giusti and colleagues showed that circTulp4 modulates excitatory synaptic strength. Knocking down circTulp4 disrupts the excitation-inhibition (E/I) balance in mice and leads to hypersensitivity toward aversive stimuli. These observations update our appreciation of the functions of circular (circ)RNA in the nervous system and their potential implication in neurodevelopmental and neuropsychiatric disorders.
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Base de dados:
MEDLINE
Assunto principal:
Sinapses
Limite:
Animals
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article