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The role of TRPA1 and TRPV1 in the perception of astringency.
Kim, Min Sung; Simons, Christopher T.
Afiliação
  • Kim MS; Department of Food Science & Technology, The Ohio State University, 2015 Fyffe Rd, Columbus, OH 43210, United States.
  • Simons CT; Department of Food Science & Technology, The Ohio State University, 2015 Fyffe Rd, Columbus, OH 43210, United States.
Chem Senses ; 492024 Jan 01.
Article em En | MEDLINE | ID: mdl-39223911
ABSTRACT
Astringency, commonly described as a drying, roughening, and/or puckering sensation associated with polyphenol-rich foods affects their palatability. While the compounds eliciting astringency are known, its mechanism of action is debated. This study investigated the role of transient receptor potential (TRP) channels A1 and V1 in astringency perception. If TRP A1 or V1 have a functional role in astringency perception, then desensitizing these receptors should decrease perceived astringency. Thirty-seven panelists underwent unilateral lingual desensitization of TRP A1 and V1 channels using mustard oil and capsaicin, respectively. Panelists then evaluated four astringent stimuli epicatechin (EC), epigallocatechin gallate (EGCG), tannic acid (TA), and potassium alum (Alum), via 2-AFC and intensity ratings. When TRPA1 receptors were desensitized on one half of the tongue via mustard oil, no significant differences were observed between the treated and untreated sides for both 2-AFC and intensity ratings. Similarly, when TRPV1 receptors were desensitized on one half of the tongue via capsaicin, no significant differences were observed between the treated and untreated sides for both 2-AFC and intensity ratings. These findings challenge the notion that TRP channels play a pivotal role in astringency perception.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Taninos / Óleos de Plantas / Capsaicina / Canais de Cátion TRPV / Canal de Cátion TRPA1 / Mostardeira Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Taninos / Óleos de Plantas / Capsaicina / Canais de Cátion TRPV / Canal de Cátion TRPA1 / Mostardeira Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2024 Tipo de documento: Article