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Better cardiovascular health is associated with slowed clinical progression in autosomal dominant frontotemporal lobar degeneration variant carriers.
VandeBunte, Anna M; Lee, Hyunwoo; Paolillo, Emily W; Hsiung, Ging-Yuek Robin; Staffaroni, Adam M; Saloner, Rowan; Tartaglia, Carmela; Yaffe, Kristine; Knopman, David S; Ramos, Eliana Marisa; Rascovsky, Katya; Bozoki, Andrea C; Wong, Bonnie; Domoto-Reilly, Kimiko; Snyder, Allison; Pressman, Peter; Mendez, Mario F; Litvan, Irene; Fields, Julie A; Galasko, Douglas R; Darby, Ryan; Masdeu, Joseph C; Pasqual, Maria Belen; Honig, Lawrence S; Ghoshal, Nupur; Appleby, Brian S; Mackenzie, Ian R; Heuer, Hilary W; Kramer, Joel H; Boxer, Adam L; Forsberg, Leah K; Boeve, Brad; Rosen, Howard J; Casaletto, Kaitlin B.
Afiliação
  • VandeBunte AM; Department of Neurology, University of California, San Francisco, Memory and Aging Center, San Francisco, California, USA.
  • Lee H; Department of Psychology, Palo Alto University, Palo Alto, California, United States.
  • Paolillo EW; Division of Neurology, UBC Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
  • Hsiung GR; Department of Neurology, University of California, San Francisco, Memory and Aging Center, San Francisco, California, USA.
  • Staffaroni AM; Division of Neurology, UBC Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
  • Saloner R; Department of Neurology, University of California, San Francisco, Memory and Aging Center, San Francisco, California, USA.
  • Tartaglia C; Department of Neurology, University of California, San Francisco, Memory and Aging Center, San Francisco, California, USA.
  • Yaffe K; Tanz Centre for Research in Neurodegenerative Diseases, Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
  • Knopman DS; Department of Neurology, University of California, San Francisco, Memory and Aging Center, San Francisco, California, USA.
  • Ramos EM; Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
  • Rascovsky K; David Geffen School of Medicine at UCLA, UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, California, USA.
  • Bozoki AC; Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Wong B; Department of Neurology, University of North Carolina, Chapel Hill, North Carolina, USA.
  • Domoto-Reilly K; Harvard Massachusetts General Hospital Frontotemporal Disorders Unit, Charlestown, Massachusetts, USA.
  • Snyder A; Department of Neurology, University of Washington, Seattle, Washington, USA.
  • Pressman P; National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA.
  • Mendez MF; Department of Neurology, University of Colorado School of Medicine, Aurora, Colorado, USA.
  • Litvan I; David Geffen School of Medicine at UCLA, Reed Neurological Research Center, Los Angeles, California, USA.
  • Fields JA; San Diego Department of Neurosciences, University of California, San Diego, La Jolla, California, USA.
  • Galasko DR; Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
  • Darby R; San Diego Department of Neurosciences, University of California, San Diego, La Jolla, California, USA.
  • Masdeu JC; Department of Neurology, Vanderbilt University, Nashville, Tennessee, USA.
  • Pasqual MB; Houston Methodist Neurological Institute, Houston, Texas, USA.
  • Honig LS; Houston Methodist Neurological Institute, Houston, Texas, USA.
  • Ghoshal N; Department of Neurology, Irving Medical Center, Columbia University, New York, New York, USA.
  • Appleby BS; Department of Neurology, St. Louis School of Medicine, Washington University, St. Louis, Missouri, USA.
  • Mackenzie IR; Department of Neurology, Case Western Reserve University, Cleveland, Ohio, USA.
  • Heuer HW; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
  • Kramer JH; Department of Neurology, University of California, San Francisco, Memory and Aging Center, San Francisco, California, USA.
  • Boxer AL; Department of Neurology, University of California, San Francisco, Memory and Aging Center, San Francisco, California, USA.
  • Forsberg LK; Department of Neurology, University of California, San Francisco, Memory and Aging Center, San Francisco, California, USA.
  • Boeve B; Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
  • Rosen HJ; Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
  • Casaletto KB; Department of Neurology, University of California, San Francisco, Memory and Aging Center, San Francisco, California, USA.
Alzheimers Dement ; 2024 Sep 06.
Article em En | MEDLINE | ID: mdl-39240048
ABSTRACT

INTRODUCTION:

Cardiovascular health is important for brain aging, yet its role in the clinical manifestation of autosomal dominant or atypical forms of dementia has not been fully elucidated. We examined relationships between Life's Simple 7 (LS7) and clinical trajectories in individuals with autosomal dominant frontotemporal lobar degeneration (FTLD).

METHODS:

Two hundred forty-seven adults carrying FTLD pathogenic genetic variants (53% asymptomatic) and 189 non-carrier controls completed baseline LS7, and longitudinal neuroimaging and neuropsychological testing.

RESULTS:

Among variant carriers, higher baseline LS7 is associated with slower accumulation of frontal white matter hyperintensities (WMHs), as well as slower memory and language declines. Higher baseline LS7 associated with larger baseline frontotemporal volume, but not frontotemporal volume trajectories.

DISCUSSION:

Better baseline cardiovascular health related to slower cognitive decline and accumulation of frontal WMHs in autosomal dominant FTLD. Optimizing cardiovascular health may be an important modifiable approach to bolster cognitive health and brain integrity in FTLD. HIGHLIGHTS Better cardiovascular health associates with slower cognitive decline in frontotemporal lobar degeneration (FTLD). Lifestyle relates to the accumulation of frontal white matter hyperintensities in FTLD. More optimal cardiovascular health associates with greater baseline frontotemporal lobe volume. Optimized cardiovascular health relates to more favorable outcomes in genetic dementia.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article