Insulin resistance is associated to future hypertension in normotensive salt-sensitive individuals: a 10-year follow-up study.
J Hypertens
; 2024 Jul 15.
Article
em En
| MEDLINE
| ID: mdl-39248115
ABSTRACT
BACKGROUND:
Salt-sensitive hypertension is associated with insulin resistance in nonobese individuals. However, no data have been reported for normotensive offspring of hypertensive salt-sensitive parents.AIMS:
To evaluate in normotensive salt-sensitive or salt-resistant offspring of hypertensive parents (offSS-HT and offSR-HT, respectively) the possible association between insulin resistance and endothelial dysfunction, and the risk of developing hypertension in a 10-year follow-up. DESIGN ANDMETHODS:
Forty-one offSS-HT (29â±â2âyears; 20 female) and 36 offSR-HT (25â±â3âyears; 16 female) were followed up for 10âyears. Both groups were considered lean. At baseline, creatinine clearance (CrCl), 24âh urinary albumin excretion (UAE), glycemia, and insulinemia were measured before and after 60 and 120âmin of glucose overload (75âg). HOMA Index and the area under the curve (AUC) were calculated. Blood pressure (BP) and 24âh urine sodium excretion was measured annually. Postischemic minimum vascular resistance (forearm plethysmography) was assessed at baseline.RESULTS:
In offSS-HT, UAE (53â±â3âmg/min) and CrCl (136â±â8âml/min) were higher in offSS-HT than in offSR-HT. (UAE 12â±â4âmg.min; p,0.01 and CrCl 107â±â6âml.min; Pâ<â0.01). An impaired vasodilatory postischemic response was observed in offSS-HT compared with offSR-HT (Pâ<â0.01). In offSS-HT glycemia, insulin, AUC at 69 and 120 min post OTG were greater than in offSS-HT, pâ<â0.02. In offSS-HT, blood pressure rose (Pâ<â0.01) the 10âyears follow-up compared with offSR-HT.CONCLUSION:
Salt sensitivity in the offspring of hypertensive salt-sensitive individuals is associated with insulin resistance and endothelial dysfunction and is prone to hypertension over a short period of time.
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Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article