Proanthocyanidins alleviate Henoch-Schönlein purpura by mitigating inflammation and oxidative stress through regulation of the TLR4/MyD88/NF-κB pathway.
Skin Res Technol
; 30(9): e13921, 2024 Sep.
Article
em En
| MEDLINE
| ID: mdl-39252568
ABSTRACT
OBJECTIVE:
Investigate Proanthocyanidins (PCs) efficacy and mechanisms in treating Henoch-Schönlein purpura (HSP)-like rat models, focusing on inflammatory and oxidative stress (OS) responses.METHODS:
An HSP-like rat model was established using ovalbumin (OVA) injection, leading to symptoms mimicking HSP. The study measured inflammatory markers (IL-4, IL-17, TNF-α), OS markers (MDA, SOD, CAT), and assessed the TLR4/MyD88/NF-κB signaling pathway's involvement via histopathological and immunofluorescence analyses.RESULTS:
PCs treatment significantly improved HSP-like symptoms, reduced inflammatory cell infiltration, and decreased IgA deposition in renal mesangial areas. Serum analyses revealed that PCs effectively lowered IL-4, IL-17, TNF-α, and MDA levels while increasing SOD and CAT levels (p < 0.05). Crucially, PCs also downregulated TLR4, MyD88, and NF-κB expressions, highlighting the blockage of the TLR4-mediated signaling pathway as a key mechanism.CONCLUSION:
PCs show promising therapeutic effects in HSP-like rats by mitigating inflammatory responses and oxidative damage, primarily through inhibiting the TLR4/MyD88/NF-κB pathway. These findings suggest PCs as a potential treatment avenue for HSP, warranting further investigation.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Vasculite por IgA
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Transdução de Sinais
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NF-kappa B
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Estresse Oxidativo
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Proantocianidinas
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Modelos Animais de Doenças
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Receptor 4 Toll-Like
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Fator 88 de Diferenciação Mieloide
Limite:
Animals
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article