Necrotising enterocolitis suspicion in newborns with duct-dependent congenital heart disease: prognosis and risk factor.
BMJ Paediatr Open
; 8(1)2024 Sep 15.
Article
em En
| MEDLINE
| ID: mdl-39284616
ABSTRACT
INTRODUCTION:
The main risk factors of necrotising enterocolitis (NEC) are prematurity and low birth weight. The aim of our study was to identify risk factors for NEC in patients with duct-dependent congenital heart disease (CHD). STUDYDESIGN:
Newborns with duct-dependent CHD and NEC were matched 11 to those without NEC. Matched criteria were gestational age, birth weight, antenatal versus postnatal diagnosis and type of CHD.RESULTS:
Twenty-three infants were included in each group. In the NEC group, mortality, length of intensive care unit stay and length of hospital stay were significantly higher (p=0.035; p<0.0001; p<0.0001). Lower diastolic blood pressure (DBP), negative flow balance, peritoneal dialysis and epinephrine-infusion were significantly associated with NEC (respectively, p=0.008, p=0.002, p=0.007, p=0.017). In multivariate analysis, DBP≤30 mm Hg remained the only independent risk factor of NEC (OR=8.70; 95% CI (1.46 to 53.50), p=0.019).CONCLUSION:
A DBP lower than 30 mm Hg was in our matched population of newborns with duct-dependent CHD, independently associated with NEC.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Enterocolite Necrosante
/
Cardiopatias Congênitas
Limite:
Female
/
Humans
/
Male
/
Newborn
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article