Endorphin activity in childhood psychosis. Spinal fluid levels in 24 cases.
Arch Gen Psychiatry
; 42(8): 780-3, 1985 Aug.
Article
em En
| MEDLINE
| ID: mdl-4015322
ABSTRACT
Twenty 2- to 13-year-old infantile autistic children (16 boys and four girls) and four 4- to 13-year-old children (two boys and two girls) with other kinds of childhood psychoses were compared with eight 6-month-old to 6-year-old normal children with regard to cerebrospinal fluid contents of endorphin fractions I and II. The psychosis groups showed higher mean cerebrospinal fluid endorphin fraction II levels, and 11 (55%) of the 20 autistic patients showed values higher than the highest in the group of normal children. There was a trend toward a correlation between high fraction II levels and self-destructiveness and decreased pain sensibility in the psychotic children. The results are regarded as preliminary but as warranting further research in this potentially fruitful field.
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Base de dados:
MEDLINE
Assunto principal:
Transtornos Psicóticos
/
Transtorno Autístico
/
Endorfinas
Tipo de estudo:
Diagnostic_studies
Limite:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
1985
Tipo de documento:
Article