[Effect of cyclophosphamide on the ganglioside content and profile in metastasizing and nonmetastasizing mammary carcinoma in mice]. / Vliianie tsiklofosfamida na soderzhanie i profil' gangliozidov v metastaziruiushchei i nemtastaziruiushchei kartsinome molochnoi zhelezy myshei.

ABSTRACT

The content and profile of gangliosides (Gs) were investigated in metastatic (HMC-L) and nonmetastatic (HMC-O) mouse mammary carcinomas before and after cyclophosphamide (CP) treatment. It was shown that the Gs content did not alter markedly during HMC-O growth, whereas in HMC-L, it increased to maximum on day 15 after tumor inoculation and then dropped. CP treatment led to a steady rise in the Gs content in both tumors. The main Gs in HMC-O corresponded to GDIa, GMI, GDIb and hematosides, while in HMC-L, the main Gs at days 9-15 after tumor inoculation corresponded to GDIa (50-65% of total Gs). The action of CP on HMC-O was not accompanied by any essential alterations in the Gs profile, whereas in HMC-L on days 3-6 after CP treatment the relative content of GDIa was significantly lowered and the GMI and hematoside content markedly increased. These findings indicate that there is an obvious relation between the Gs profile and tumor ability to form metastases.