Changes in atrial biopsies in chronic rheumatic heart disease. II: Muscle fibre reaction.
Pathol Res Pract
; 179(6): 600-9, 1985 May.
Article
em En
| MEDLINE
| ID: mdl-4022837
ABSTRACT
Myocardial fibres were studied in the right atrial biopsies from 32 patients with chronic rheumatic heart disease (RHD). Paraffin and, particularly, araldite sections showed many muscle fibres well preserved, and others with large hyperchromatic nuclei, or with depleted myofibrils and increased mitochondria. With the SDH and ATPase reactions, there was no type difference in the myocardial fibres, and the former showed the reaction predominantly in the centre while the latter showed it mainly at the periphery of the fibres. At electronmicroscopy, fibres with intact myofibrils were found close to "degenerating" fibres with variable degrees of myofibrillar and myofilament disorganisation and loss, mitochondrial proliferation, occasionally with degeneration of cristae, and accumulation of lipofuscin in varying amounts, and irregularly tortuous or loosened intercellular junctions. This study has revealed more severe muscle changes than expected, even in the clinically less affected right atrial chamber in chronic RHD. It is speculated that this might be due to subclinical involvement of the tricuspid valve, known to be frequent in Indian patients, and the resulting "back pressure" on the right atrium might lead to changes in its myofibres.
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Base de dados:
MEDLINE
Assunto principal:
Cardiopatia Reumática
/
Miocárdio
Limite:
Adolescent
/
Adult
/
Child
/
Humans
/
Middle aged
Idioma:
En
Ano de publicação:
1985
Tipo de documento:
Article