Synergistic activity of combinations of recombinant human alpha interferon and acyclovir, administered concomitantly and in sequence, against a lethal herpes simplex virus type 1 infection in mice.
Antimicrob Agents Chemother
; 28(1): 1-4, 1985 Jul.
Article
em En
| MEDLINE
| ID: mdl-4037769
The nucleoside analog acyclovir [9-(2-hydroxyethoxymethyl)guanine] and the hybrid recombinant human alpha interferon (rHuIFN-alpha A/D) were evaluated in weanling mice for their efficacy alone and in combination against a lethal systemic infection with herpes simplex virus type 1. Simultaneous parenteral treatment with combinations of both agents at various doses resulted in a higher percentage of survival than when either agent was administered alone, with a synergistic interaction demonstrated at certain dose combinations. Sequential administration of parenteral rHuIFN-alpha A/D and oral acyclovir, administered by gavage or supplied ad libitum in drinking water, resulted in a synergistic interaction at all dose combinations tested. These results suggest that combinations of interferon and acyclovir may be useful in treating primary herpes simplex virus infections in humans.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Aciclovir
/
Interferon Tipo I
/
Herpes Simples
Limite:
Animals
Idioma:
En
Ano de publicação:
1985
Tipo de documento:
Article