Diabetes in the Bio-Breeding/Worcester rat. Induction and acceleration by spleen cell-conditioned media.
J Clin Invest
; 76(4): 1692-4, 1985 Oct.
Article
em En
| MEDLINE
| ID: mdl-4056046
ABSTRACT
Injections of media conditioned by concanavalin A-activated spleen cells from acutely diabetic rats accelerated the appearance of diabetes in young Bio-Breeding/Worcester (BB/W) rats. Activity was also found in media conditioned by spleen cells from nondiabetic, W-line Wistar Furth and Buffalo rats. Unconditioned media containing mitogen had no activity. Conditioned media also induced diabetes in resistant W-line BB/W rats but not in Wistar Furth rats. A soluble factor may activate a BB lymphocyte population that promotes diabetes.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ratos Endogâmicos
/
Doenças Autoimunes
/
Baço
/
Ratos Endogâmicos BB
/
Diabetes Mellitus Tipo 1
Limite:
Animals
Idioma:
En
Ano de publicação:
1985
Tipo de documento:
Article