Suppression of growth of Ehrlich ascites tumor cells in mice by trehalose-6,6'-dimycolate (cord factor) and BCG.
Infect Immun
; 9(6): 977-84, 1974 Jun.
Article
em En
| MEDLINE
| ID: mdl-4208531
ABSTRACT
Growth of Ehrlich ascites tumor cells in mice pretreated with cord factor was compared to growth of the tumor cells after pretreatment with Calmette-Guérin bacilli. Growth of Ehrlich ascites cells was strongly inhibited in the peritoneal cavities of mice pretreated with 80 mug of cord factor. The median survival time of the animals was prolonged (70 versus 17 days), and 40% of the mice survived more than 90 days. Tumor suppression was still detectable 36 days after administration of cord factor. The effect of cord factor was local. Comparable results were obtained with living or killed Calmette-Guérin bacilli. The results are discussed.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Glicolipídeos
/
Carcinoma de Ehrlich
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Dissacarídeos
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Mycobacterium tuberculosis
Limite:
Animals
Idioma:
En
Ano de publicação:
1974
Tipo de documento:
Article