Nicotinamide-adenine dinucleotide in tubercle bacilli exposed to isoniazid.
Science
; 152(3721): 525-6, 1966 Apr 22.
Article
em En
| MEDLINE
| ID: mdl-4286359
ABSTRACT
There is a decrease in the content of nicotinamide-adenine dinucleotide of tubercle bacilli grown in the presence of isoniazid. In extracts of tubercle bacilli, the activity of nicotinamide-adenine dinucleotidase is nil or very small; after incubation with the drug the enzyme becomes active. Isoniazid also increases the activity of the enzyme after it is partially activated by heating. There may be a correlation between the capacity of isoniazid to activate the enzyme and the decrease in the dinucleotide content of the tubercle bacilli.
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Base de dados:
MEDLINE
Assunto principal:
Isoniazida
/
Mycobacterium tuberculosis
/
NAD
/
Nucleotidases
Idioma:
En
Ano de publicação:
1966
Tipo de documento:
Article