SK&F 92657, a novel antihypertensive acting by precapillary vasodilatation and beta-adrenoreceptor blockade.
Clin Sci (Lond)
; 57 Suppl 5: 433s-436s, 1979 Dec.
Article
em En
| MEDLINE
| ID: mdl-44235
ABSTRACT
1. The properties of a new antihypertensive agent, SK&F 92657, DL-3-[2-(3-t-butylamino-2-hydroxypropoxy)phenyl]-6-hydrazinopyridazine, have been studied. 2. The compound caused a sustained fall in blood pressure in several species as a result of precapillary vasodilatation, particularly in the renal and coronary vasculatures. 3. The beta-adrenoreceptor-blocking actions of SK&F 92657 prevent reflex cadiac stimulation.
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Base de dados:
MEDLINE
Assunto principal:
Piridazinas
/
Vasodilatação
/
Vasodilatadores
/
Pressão Sanguínea
/
Receptores Adrenérgicos
/
Receptores Adrenérgicos beta
/
Antagonistas Adrenérgicos beta
/
Frequência Cardíaca
/
Hipertensão
Limite:
Animals
Idioma:
En
Ano de publicação:
1979
Tipo de documento:
Article