Decrease in free cystine content of cultured cystinotic fibroblasts by ascorbic acid.
Science
; 186(4168): 1040-2, 1974 Dec 13.
Article
em En
| MEDLINE
| ID: mdl-4469696
ABSTRACT
The 100-fold increase in free cystine content characteristic of cultured skin fibroblasts from patients with nephropathic cystinosis was decreased more than 50 percent by addition of L-ascorbic acid to the culture medium at concentrations of 0.29 to 2.9 millimolar. Fresh ascorbic acid must be added to the culture medium daily to produce a progressive decrease of the free cystine content of the cells over a 3-day period. Upon removal of ascorbic acid from the medium, the free cystine content returns to its initial value.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Ácido Ascórbico
/
Cistina
/
Cistinose
Idioma:
En
Ano de publicação:
1974
Tipo de documento:
Article