Saccharin metabolism and tumorigenicity.
Science
; 205(4410): 1019-20, 1979 Sep 07.
Article
em En
| MEDLINE
| ID: mdl-472722
ABSTRACT
Exposure of male Charles River CDI rats to a 5% saccharin diet in utero and throughout weaning, conditions associated with tumor induction, did not induce detectable metabolism (less than 0.4% of the oral dose) of tritiated saccharin in vivo. No metabolites (less than 0.06 microgram per kilogram per 24 hours) were detected in the urine of normal rats given a tracer dose. Pretreatment with 3-methylcholanthrene did not induce saccharin metabolism.
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Base de dados:
MEDLINE
Assunto principal:
Sacarina
/
Carcinógenos
Limite:
Animals
Idioma:
En
Ano de publicação:
1979
Tipo de documento:
Article