Conformation of N6-methyladenine, a base involved in DNA modification: restriction processes.
Science
; 182(4114): 833-4, 1973 Nov 23.
Article
em En
| MEDLINE
| ID: mdl-4746493
ABSTRACT
Crystal structures of N(6),N(9)-dimethyladenine and N(6)-methyladenine hydrochloride were determined from three-dimensional x-ray diffraction data. The bases assume a conformation in which the N(6)-methyl group blocks one of the hydrogen-bonding sites normally used by adenine to form Watson-Crick pairs with thymine in double-helical DNA. When in this conformation, N(6)-methyladenine residues might alter the secondary structure of DNA. thereby preventing the scission of modified DNA's by restriction enzymes.
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Base de dados:
MEDLINE
Assunto principal:
DNA
/
Adenina
Idioma:
En
Ano de publicação:
1973
Tipo de documento:
Article