Water-soluble derivatives of 1 -tetrahydrocannabinol.
Science
; 177(4047): 442-4, 1972 Aug 04.
Article
em En
| MEDLINE
| ID: mdl-5043146
ABSTRACT
Delta1-Tetrahydrocannabinol, which is resinous and insoluble in water and therefore difficult to study pharmacologically, can be converted to a watersoluble derivative without loss of its biological activity. This has been achieved by preparing esters bearing a nitrogen moiety with the use of carbodiimide as the condensing agent. The availability of such water-soluble derivatives will allow the evaluation of Delta1-tetrahydrocannabinol in self-administration studies in monkeys for its addiction liability potential in man. This technique of water solubilization is also applicable to other compounds of chemical and biological significance.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Cannabis
Limite:
Animals
Idioma:
En
Ano de publicação:
1972
Tipo de documento:
Article