Immunological alterations in the lungs of mice following ozone exposure: changes in immunoglobulin levels and antibody-containing cells.
Arch Environ Health
; 34(4): 258-65, 1979.
Article
em En
| MEDLINE
| ID: mdl-573102
ABSTRACT
Ozone was added to the air of the environmental chambers containing specific pathogen-free mice. At levels of 0.5 and 0.8 ppm the oxidant was seen to have inflammatory effects, as shown by rising serum albumin levels in lung lavage fluid. Fluorescein conjugated anti-heavy chain sera were used to detect cells containing IgM, IgG, and IgA in measured lung areas termed Pulmonary Units. Antigenic stimuli occurred along the airways, with significant increases of IgA-containing cells in the bronchus-associated lymphoid tissue. The numbers of IgM- and IgG-containing cells did not increase. Immunodiffusion analyses for immunoglobulins in lung lavage fluid indicated increases of IgG1, IgG2, and IgA in lung secretions. The calculation of changing Ig/Alb ratios suggested that the IgA present was largely the result of local synthesis, while IgG molecules were mainly of serum origin. Possible sources of antigenic stimuli to ozone-exposed lungs are discussed.
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Base de dados:
MEDLINE
Assunto principal:
Ozônio
/
Imunoglobulinas
/
Imunidade
/
Pulmão
/
Células Produtoras de Anticorpos
Limite:
Animals
Idioma:
En
Ano de publicação:
1979
Tipo de documento:
Article