Actions of adrenaline on the potassium balance of the isolated heart.
Br J Pharmacol
; 36(3): 571-81, 1969 Jul.
Article
em En
| MEDLINE
| ID: mdl-5789810
ABSTRACT
1. The action of adrenaline on the K(+) balance of the isolated heart was found to depend on the ionic composition and the temperature of the perfusion fluids used.2. When the perfusion fluid contained 145 mM Na(+), 1.7 mM Ca(++) and 3-9 mM K(+), adrenaline caused the hearts to gain K(+); when the K(+) concentration was reduced to 1.2 mM, adrenaline caused a loss of K(+). Both were actions on beta receptors.3. When the Ca(++) or the Na(+) concentration in the perfusion fluid was reduced, together with a reduction in K(+), adrenaline no longer produced K(+) loss from the hearts, but produced a gain of K(+).4. When the temperature of the perfusion fluid was reduced to 25 degrees C, adrenaline still produced a gain of K(+) by hearts perfused with fluid containing 3.2 mM K(+), but did not produce a loss of K(+) from hearts perfused with fluid containing 1.2 mM K(+).
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Potássio
/
Epinefrina
/
Coração
/
Miocárdio
Limite:
Animals
Idioma:
En
Ano de publicação:
1969
Tipo de documento:
Article