Ovulation inhibition with a log-acting injectable. II. The cycling effects of varying progestagen-estrogen combinations.
Am J Obstet Gynecol
; 94(2): 161-4, 1966 Jan 15.
Article
em En
| MEDLINE
| ID: mdl-5900652
ABSTRACT
PIP The cycling effects of long-term injectable progestational compounds were studied to determine the most satisfactory dosage level. The compound Deladroxate (Deladroxone and estradiol enanthate) was administered to 38 subjects in the 5 following doses 150 mg Deladroxone with 5 mg, 10 mg, 15 mg estradiol enanthate; and 200 mg Deladroxone with 5 mg or 20 mg estradiol enanthate. The compounds Deladroxate 150-10 and Deladroxate 200-5 showed the most satisfactory cycling and aftereffects. Further study of Deladroxate 150-10 showed mean cycle lengths of 26.2 and 28.3 days in 143 cycles, a 16% deviation of plus or minus 2 days from a pretreatment means, minimal side effects, and ovulatory cycles that returned within 5 to 13 weeks after withdrawal of the drug.^ieng
Palavras-chave
Algestone Acetophenide--administraction and dosage; Algestone Acetophenide--side effects; Anovulation; Biology; Body Weight; Clinical Research; Contraception; Contraceptive Agents, Estrogen--administraction and dosage; Contraceptive Agents, Estrogen--side effects; Contraceptive Agents, Female--administraction and dosage; Contraceptive Agents, Female--side effects; Contraceptive Agents, Progestin--administraction and dosage; Contraceptive Agents, Progestin--side effects; Contraceptive Agents--administraction and dosage; Contraceptive Agents--side effects; Ethinyl Estradiol--administraction and dosage; Ethinyl Estradiol--side effects; Evaluation; Family Planning; Genitalia; Genitalia, Female; Human Volunteers; Injectables; Mammary Gland Effects; Menstrual Cycle; Menstruation; Menstruation Disorders; Multiparity; Ovarian Effects; Ovary; Ovulation Suppression; Physiology; Reproduction; Research Methodology; Reversibility; Urogenital System
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Base de dados:
MEDLINE
Assunto principal:
Progestinas
/
Dispositivos Anticoncepcionais
Idioma:
En
Ano de publicação:
1966
Tipo de documento:
Article