The action of the sodium ionophore, monensin, or transmitter release at the frog neuromuscular junction.
Brain Res
; 204(1): 204-8, 1981 Jan 05.
Article
em En
| MEDLINE
| ID: mdl-6113873
ABSTRACT
The action of the sodium ionophore, monensin, on spontaneous and evoked transmitter release at the frog neuromuscular junction was studied. Ringer's solutions with low calcium concentrations (0.4 mM or 0 Ca 1 mM EGTA) were used to bathe the preparation. Following addition of monensin in the bathing solution (1) substantial increases in miniature end-plate potential frequency occurred; (2) tetanic nerve stimulation caused increases in potentiation of approximately 10 times over control values; (3) there was a dual action on the amplitude of the end-plate potential. We conclude that sodium ions take part in the regulation of transmitter release at the neuromuscular junction.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Monensin
/
Furanos
/
Junção Neuromuscular
Limite:
Animals
Idioma:
En
Ano de publicação:
1981
Tipo de documento:
Article