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Interaction of neuroleptic drugs with a synthetic calcium-binding peptide analog of site III of rabbit skeletal troponin C. Phenothiazine selective binding.
FEBS Lett ; 154(1): 60-4, 1983 Apr 05.
Article em En | MEDLINE | ID: mdl-6131840
The effects of nine drugs on the CD spectra of a synthetic calcium binding analog of site III of rabbit skeletal troponin C, can generally be divided into 3 groups: (1) that consisting of haloperidol, benperidol, molindone and promethazine, had no effect on the CD spectrum or calcium sensitivity of the apopeptide; (2) that composed of structurally rigid thioxanthenes, induced CD-detectable structural change in the apopeptide but prevented Ca2+-induced structural change; (3) that consisting of chlorpromazine, trifluoperazine and fluphenazine, induced structural change in the peptide but had no effect on the Ca2+-induced structural change.
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Base de dados: MEDLINE Assunto principal: Peptídeos / Antipsicóticos / Troponina / Cálcio / Proteínas Musculares Limite: Animals Idioma: En Ano de publicação: 1983 Tipo de documento: Article
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Base de dados: MEDLINE Assunto principal: Peptídeos / Antipsicóticos / Troponina / Cálcio / Proteínas Musculares Limite: Animals Idioma: En Ano de publicação: 1983 Tipo de documento: Article