Kappa binding sites in guinea-pig brain membranes: evidence for a dynorphin-resistant subtype.
Life Sci
; 33 Suppl 1: 179-82, 1983.
Article
em En
| MEDLINE
| ID: mdl-6141484
ABSTRACT
Using [3H]ethylketocyclazocine after suppression of mu, delta and sigma binding by 100 nM DAGO + 100 nM DADLE + 10 microM phencyclidine we showed the existence of a subclass of kappa sites insensitive to dynorphins 1-9 and 1-17, and alpha and beta neoendorphins, but sensitive to the non-peptidic opiates. The dynorphin-sensitive site probably corresponds to the "standard" kappa site while the importance of the dynorphin-resistant site remains to be established.
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Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Receptores Opioides
Limite:
Animals
Idioma:
En
Ano de publicação:
1983
Tipo de documento:
Article