Synchronizing, sedative and anticonvulsive effects of centrally administered somatostatin in the conscious rabbit.
Regul Pept
; 9(1-2): 77-86, 1984 Sep.
Article
em En
| MEDLINE
| ID: mdl-6150519
ABSTRACT
The effects of intracerebroventricular injection of somatostatin-14 on the cortical and deep structure electrical activity, somatic behavior and rectal temperature, were studied in 45 unanesthetized rabbits. In addition the antiepileptic action of the peptide was tested in these models pentamethylenetetrazole-induced cortical spikes and waves, epileptic focus by topical application of strychnine and voltage-threshold for amygdala after-discharge. The results indicate that somatostatin exerts synchronizing, sedative and weak antiepileptic effects when centrally administered to rabbits.
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Base de dados:
MEDLINE
Assunto principal:
Somatostatina
/
Sistema Nervoso Central
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
1984
Tipo de documento:
Article