The purification and characterization of a lymphokine chemotactic for lymphocytes--lymphotactin.
Inflammation
; 2(2): 105-13, 1977 Jun.
Article
em En
| MEDLINE
| ID: mdl-617802
ABSTRACT
Aqueous extracts of the thymus from vaccinated calves contain a protein specifically chemotactic for lymphocytes (lymphotactin). Lymphotactin has been isolated and purified by ethanol fractionation, ultrafiltration, isoelectric focusing, and preparative acrylamide gel electrophoresis. Its isoelectric point is 5.9, and the molecular weight by both SDS electrophoresis and exclusion chromatography is about 10,500. The purified sialoprotein is homogeneous at three different pH's in acrylamide gel electrophoresis. As little as 1 microgram of this material intraperitoneally wlll produce massive lymphocyte infiltration within 4 h in vivo.
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Base de dados:
MEDLINE
Assunto principal:
Sialoglicoproteínas
/
Quimiotaxia de Leucócito
/
Linfocinas
Limite:
Animals
Idioma:
En
Ano de publicação:
1977
Tipo de documento:
Article