Novel opiates and antagonists. 4. 7-Alkanoylhydromorphones.
J Med Chem
; 25(8): 983-6, 1982 Aug.
Article
em En
| MEDLINE
| ID: mdl-6181259
ABSTRACT
A series of 7-alkanoyl-substituted hydromorphone derivatives were prepared by acylation of the morpholine enamines. The most potent compound (6i) of the series was found to have agonist activity of the same order of magnitude as that of buprenorphine. The N-cyclopropylmethyl-substituted series was found to exhibit structure-activity relationships for analgesia and narcotic antagonism similar to those of the endo-ethanotetrahydrooripavines.
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Base de dados:
MEDLINE
Assunto principal:
Hidromorfona
/
Antagonistas de Entorpecentes
/
Entorpecentes
Limite:
Animals
Idioma:
En
Ano de publicação:
1982
Tipo de documento:
Article