Cytotoxic T lymphocyte recognition of the influenza hemagglutinin gene product expressed by DNA-mediated gene transfer.
J Exp Med
; 159(2): 341-54, 1984 Feb 01.
Article
em En
| MEDLINE
| ID: mdl-6198429
ABSTRACT
We have used the technique of DNA-mediated gene transfer to examine cytotoxic T lymphocyte (CTL) recognition of the product of the cloned A/JAPAN/305/57 hemagglutinin (HA) gene in murine (L929) cells. Using both heterogeneous and homogeneous (clonal) populations of type A influenza-specific CTL, we have demonstrated that the HA molecule can serve as a target antigen for both the subtype-specific and the cross-reactive subpopulations of influenza-specific CTL. Our results also raise the possibility that other virus-specified polypeptides may serve as target molecules for cross-reactive CTL.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Biossíntese de Proteínas
/
Linfócitos T Citotóxicos
/
Infecções por Orthomyxoviridae
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Hemaglutininas Virais
Limite:
Animals
Idioma:
En
Ano de publicação:
1984
Tipo de documento:
Article