Injection-site granuloma due to aluminum.
Arch Dermatol
; 120(10): 1318-22, 1984 Oct.
Article
em En
| MEDLINE
| ID: mdl-6207779
ABSTRACT
Three patients had subcutaneous nodules at the sites of previous injections of vaccine containing tetanus toxoid. Biopsy and microscopic findings in all three cases showed foci of granulomatous inflammation, consisting of lymphoid follicles, in the deep dermis and subcutaneous tissues and a surrounding infiltrate of lymphocytes, histiocytes, plasma cells, and eosinophils. Occasional zones of eosinophilic necrosis were seen within the inflammatory foci, and surrounding dense fibrous bands were present in some areas. A solochrome-azurin stain showed aluminum crystals in the nodules from two patients. From the evidence available, we believe that these nodules are a complication of inoculations with aluminum-containing vaccines.
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Base de dados:
MEDLINE
Assunto principal:
Dermatopatias
/
Toxoide Tetânico
/
Vacinação
/
Alumínio
/
Granuloma
Limite:
Adult
/
Animals
/
Child, preschool
/
Humans
/
Male
Idioma:
En
Ano de publicação:
1984
Tipo de documento:
Article