Glycoprotein IIb-IIIa complex in platelets of patients and heterozygotes of Glanzmann's thrombasthenia.
Thromb Res
; 32(6): 615-22, 1983 Dec 15.
Article
em En
| MEDLINE
| ID: mdl-6229900
ABSTRACT
The concentration of the glycoprotein (GP) IIb-IIIa complex in thrombasthenic platelets of 8 patients of 6 families has been estimated. In the thrombasthenic platelets of 3 patients this complex is absent (thrombasthenia type I and subtype I). In 2 patients only traces are detectable and in 3 patients GP IIb-IIIa complex is strongly reduced (less than 5%). On the basis of the haemostatic data as well as the content of GP IIb-IIIa complex and platelet fibrinogen the classification of these types as subtypes of thrombasthenia type II is discussed. The diagnostic applicability of GP IIb-IIIa complex determination for heterozygote detection in types of thrombasthenia with absent or extremely reduced GP IIb-IIIa complex is shown.
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Base de dados:
MEDLINE
Assunto principal:
Transtornos Plaquetários
/
Glicoproteínas
/
Triagem de Portadores Genéticos
Limite:
Humans
Idioma:
En
Ano de publicação:
1983
Tipo de documento:
Article