Stimulation of transcription of chromatin by specific small nuclear RNAs.
Gene
; 8(2): 211-24, 1980 Jan.
Article
em En
| MEDLINE
| ID: mdl-6244212
ABSTRACT
Small molecular weight nuclear RNAs (SnRNA) purified from the chromatin of SV40-transformed W138 human fibroblasts have been found to stimulate transcription of chromatin in homologous isolated nuclei as well as in nuclei of untransformed human and monkey cells. Stimulation in normal cell nuclei involves an increase in both initiation sites and rate of elongation of RNA chains. Fractionation of the SnRNA in polyacrylamide gradient slab gels revealed that the "active" RNA was 160-175 nucleotides in length.
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Base de dados:
MEDLINE
Assunto principal:
Transcrição Gênica
/
RNA
/
Cromatina
Limite:
Humans
Idioma:
En
Ano de publicação:
1980
Tipo de documento:
Article