Medullary thyroid carcinoma identified by cell-free translation of tumor messenger ribonucleic acid in a patient with a neck mass and the syndrome of ectopic adrenocorticotropin.
J Clin Endocrinol Metab
; 52(3): 572-5, 1981 Mar.
Article
em En
| MEDLINE
| ID: mdl-6257751
ABSTRACT
We report a patient who presented with a lateral neck mass and Cushing's syndrome secondary to the ectopic production of ACTH. The initial diagnosis was a nonchromaffin paraganglioma based on conventional light and electron microscopic studies. However, during this patient's hospital course, we determined that mRNA extracted from the tumor directed the translation of a calcitonin precursor in a cell-free system. This finding led to a consideration of the diagnosis of medullary thyroid carcinoma, which was then confirmed by further endocrine and histological evaluations. This is a report of the identification of a tumor type using techniques of molecular biology.
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Base de dados:
MEDLINE
Assunto principal:
Síndrome de ACTH Ectópico
/
RNA Neoplásico
/
Neoplasias da Glândula Tireoide
/
Carcinoma
/
Síndromes Endócrinas Paraneoplásicas
Tipo de estudo:
Prognostic_studies
Limite:
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
1981
Tipo de documento:
Article