Ethanol and neuronal metabolism.
Pharmacol Biochem Behav
; 13 Suppl 1: 175-82, 1980.
Article
em En
| MEDLINE
| ID: mdl-6264495
ABSTRACT
The effect of ethanol on membrane enzymes (Na+, K+ and Mg2+ ATPases, 5'-nucleotidase, adenylate cyclase) alcohol dehydrogenase, aldehyde dehydrogenase and superoxide dismutase were studied in nerve cells (established cell lines, primary cultures of chick and rat brain) cultured in the presence of 100 mM ethanol, and in total rat brain, following various ethanol treatments of the rats (20% ethanol as the sole liquid source, intraperitoneal injection). The results show a difference between neuronal and glial cells. Most of the observed changes in enzymatic activities returned rapidly to control values when ethanol was withdrawn from the culture medium or from the diet. Alcohol dehydrogenase was more stimulated by ethanol than aldehyde dehydrogenase; therefore acetaldehyde may be accumulated. The inhibition of superoxide dismutase activity may allow an accumulation of cytotoxic O2- radicals in nervous tissue and may explain the polymorphism of lesions brought about by alcohol intoxication.
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Base de dados:
MEDLINE
Assunto principal:
Etanol
/
Neurônios
Limite:
Animals
Idioma:
En
Ano de publicação:
1980
Tipo de documento:
Article