Potassium stimulated 45Ca uptake by cortical slices of rat brain: effects of cyclic nucleotide derivatives.

Ichida, S; Osugi, T; Noguchi, Y; Yoshida, H

Ichida, S; Osugi, T; Noguchi, Y; Yoshida, H.

Brain Res ; 213(2): 472-5, 1981 Jun 01.

Article em En | MEDLINE | ID: mdl-6265029

ABSTRACT

ABSTRACT

The effects of dibutyryl cyclic GMP (db-cGMP) and dibutyryl cyclic AMP (db-cAMP) on potassium-stimulated 45Ca uptake by cortical slices of rat brain were investigated. db-cGMP specifically inhibited the initial rate of potassium-stimulated 45Ca uptake in a dose-dependent manner. Our findings supported the suggestion that cyclic GMP may play a regulatory role in depolarization-elicited Ca2+ influx in nerve endings in situ.

Assuntos

Bucladesina/farmacologia; Cálcio/metabolismo; Córtex Cerebral/metabolismo; GMP Cíclico/análogos & derivados; Dibutiril GMP Cíclico/farmacologia; Potássio/farmacologia; Animais; Transporte Biológico Ativo/efeitos dos fármacos; Córtex Cerebral/efeitos dos fármacos; Técnicas In Vitro; Cinética; Masculino; Ratos

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Base de dados: MEDLINE Assunto principal: Potássio / Córtex Cerebral / Cálcio / GMP Cíclico / Bucladesina / Dibutiril GMP Cíclico Limite: Animals Idioma: En Ano de publicação: 1981 Tipo de documento: Article

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