Potassium stimulated 45Ca uptake by cortical slices of rat brain: effects of cyclic nucleotide derivatives.
Brain Res
; 213(2): 472-5, 1981 Jun 01.
Article
em En
| MEDLINE
| ID: mdl-6265029
ABSTRACT
The effects of dibutyryl cyclic GMP (db-cGMP) and dibutyryl cyclic AMP (db-cAMP) on potassium-stimulated 45Ca uptake by cortical slices of rat brain were investigated. db-cGMP specifically inhibited the initial rate of potassium-stimulated 45Ca uptake in a dose-dependent manner. Our findings supported the suggestion that cyclic GMP may play a regulatory role in depolarization-elicited Ca2+ influx in nerve endings in situ.
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Base de dados:
MEDLINE
Assunto principal:
Potássio
/
Córtex Cerebral
/
Cálcio
/
GMP Cíclico
/
Bucladesina
/
Dibutiril GMP Cíclico
Limite:
Animals
Idioma:
En
Ano de publicação:
1981
Tipo de documento:
Article