DNA restriction mapping identifies the chromosome carrying the mutant Hb Presbyterian beta-globin gene.
Hum Genet
; 64(3): 263-6, 1983.
Article
em En
| MEDLINE
| ID: mdl-6309649
ABSTRACT
Restriction endonuclease mapping of cellular DNA has been used to identify chromosomes that carry the mutant Hb Presbyterian beta-globin genes in a family with individuals heterozygous for this disease. The presence of the polymorphic Hind III restriction site in the G gamma-globin gene and its absence in the A gamma-globin gene were shown to be in phase with the Hb Presbyterian mutation yielding a haplotype constellation that is diagnostic for any further affected offspring.
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Base de dados:
MEDLINE
Assunto principal:
DNA
/
Globinas
/
Hemoglobinas Anormais
/
Genes Reguladores
/
Mutação
Tipo de estudo:
Prognostic_studies
Limite:
Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
1983
Tipo de documento:
Article