[Angiotensin II potentiates the effect of ACTH on the production of cyclic AMP by bovine adrenal cells in primary culture]. / L'angiotensine II potentialise l'effet de l'ACTH sur la production d'AMP cyclique par les cellules surrénaliennes bovines en culture primaire.

The effect of Angiotensin II (AII) on ACTH-induced cyclic AMP production was studied in bovine adrenocortical cells cultured in a chemically defined serum-free medium. Immediately after collagenase dispersion, AII did not modify either the basal or the ACTH-induced cAMP production by the isolated cells. During cell culture, AII alone did not affect cAMP production. But 2 days after plating, AII increased significantly the ACTH-induced cAMP production by the culture. This potentiating effect increased with the age of culture. Sar1Ala8AII (Saralasin), a potent AII antagonist, inhibited the AII potentiating effect indicating an AII specific action.