Transplantation of T-lymphocyte-depleted bone marrow between HLA-mismatched individuals.
Transplantation
; 36(4): 369-72, 1983 Oct.
Article
em En
| MEDLINE
| ID: mdl-6353702
ABSTRACT
Four patients with acute leukemia received transplants from HLA-mismatched, related donors. Marrow cells that had been depleted of T lymphocytes using a monoclonal anti-T-lymphocyte antibody and rabbit complement were used. In vitro studies showed that 80-97% of the mature T lymphocytes were removed using this procedure. Infusion of the treated marrow was accomplished without complications, and engraftment occurred in each case. Graft-versus-host disease occurred in 3 of the 4 patients. These results show that additional manipulations of the marrow will be required to allow complete T lymphocyte removal from the marrow before the feasibility of this approach in HLA-mismatched patients can be determined.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Transplante de Medula Óssea
/
Antígenos HLA
Limite:
Adolescent
/
Adult
/
Child
/
Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
1983
Tipo de documento:
Article