Intragastric bacterial activity and nitrosation before, during, and after treatment with omeprazole.
Br Med J (Clin Res Ed)
; 289(6447): 717-9, 1984 Sep 22.
Article
em En
| MEDLINE
| ID: mdl-6434053
ABSTRACT
Ten healthy volunteers were studied before, during, and after treatment with omeprazole 30 mg daily for two weeks. On the 14th night mean nocturnal (2100-0700) intragastric acidity was significantly decreased by 75% (p less than 0.001). At 0700, 22 hours after the last dose of omeprazole, there were significant increases in the bacterial count and the nitrite and N-nitrosamine concentrations in the gastric juice (p less than 0.001). Three days later these changes had resolved. Short term treatment of healthy volunteers with omeprazole is associated with a short lived increase in the gastric bacterial flora, with endogenous production of N-nitroso compounds.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Bactérias
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Benzimidazóis
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Suco Gástrico
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Antiulcerosos
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Compostos Nitrosos
Limite:
Adult
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Humans
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Male
Idioma:
En
Ano de publicação:
1984
Tipo de documento:
Article