[Study of the molecular causes of thalassemia. II. Deletion of alpha-globin genes in hemoglobinopathy H]. / Izuchenie molekuliarnykh prichin talassemii. Soobshchenie II. Deletsii alpha-globinovykh genov pri gemoglobinopatii H.
Genetika
; 16(1): 78-85, 1980.
Article
em Ru
| MEDLINE
| ID: mdl-6449401
ABSTRACT
Genetic and molecular studies on one case of alpha-thalassemia, found in Moscow region, have demonstrated that the cause of the disease is the deletion of 3 of 4 alpha-globin genes, presenting in the human diploid genome. The level of expression of the remained alpha-globin gene is much lower than that observed in the patients from other ethnic groups. One can suggest that in this case the deletion is spread on the regulatory zones of this gene.
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Base de dados:
MEDLINE
Assunto principal:
Talassemia
/
Globinas
/
Hemoglobina H
/
Hemoglobinas Anormais
Tipo de estudo:
Etiology_studies
Limite:
Humans
/
Male
/
Middle aged
País como assunto:
Asia
/
Europa
Idioma:
Ru
Ano de publicação:
1980
Tipo de documento:
Article