Sterile cutaneous pustules: a manifestation of primary irritancy? Identification of contact pustulogens.
J Invest Dermatol
; 76(5): 381-3, 1981 May.
Article
em En
| MEDLINE
| ID: mdl-6453167
ABSTRACT
An animal model (the rabbit) was used to define which of 8 chemicals caused pustule formation on topical application. Large occlusive chambers (diameter 12 mm), petrolatum as the vehicle and wrapping contributed to efficient occlusion and pustulation. Sodium lauryl sulfate and mecuric chloride gave reproducible results and clear dose-responses indicating that this pustulation is an expression of primary irritancy. Ammonium fluoride pustulation was not reproducible; croton oil pustules were more difficult to evaluate due to simultaneous erythema and edema. Sodium arsentate, nickel sulfate and potassium iodide pustules developed at sites where the skin barriers had been damaged by a stab injury. Benzalkonium chloride caused yellow staining and edema but not pustules. Because of lack of epidemiologic data, we do not know how frequently similar findings occur in man.
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Base de dados:
MEDLINE
Assunto principal:
Dermatopatias
/
Modelos Animais de Doenças
/
Irritantes
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
1981
Tipo de documento:
Article