Distribution and metabolic behaviour of "tightly bound" acid-soluble non-histone chromosomal proteins in developing rat brain cells.

ABSTRACT

"Tightly bound" acid-soluble non-histone chromosomal proteins of rat brain were studied, and limited but detectable tissue specificity of their pattern was demonstrated. This class of proteins showed specific distribution in rat brain cells at different stages of development. The most prominent differences were observed between non-differentiated and terminally differentiated cells. In non-differentiated rat brain cells the acid-soluble non-histone protein fraction contained both metabolically labile and metabolically stable proteins, while in fully developed cells the main portion of acid-soluble proteins showed metabolic stability.