The potentiation of ototoxicity when aminooxyacetic acid and kanamycin are co-administered.
Hear Res
; 15(2): 173-8, 1984 Aug.
Article
em En
| MEDLINE
| ID: mdl-6490543
ABSTRACT
Aminooxyacetic acid (AOAA) has been shown to confer protection against noise-induced cochlear trauma [3]. We, therefore, decided to study the possible protective effect of AOAA against kanamycin (KM) ototoxicity and found, instead, that AOAA potentiated the toxicity. To produce ototoxicity in guinea pigs, KM is usually given in 10-14 daily doses of 400 mg/kg s.c. However, when combined with a single dose of AOAA (8, 11, 15, or 25 mg/kg) a single 400 mg/kg dose of KM is sufficient to cause cochlear damage. Such animals show a negative Preyer's reflex between 1 to 3 days post injection. 21 days later hearing thresholds as detected electrocochleographically at 2, 4, 8, 12 and 16 kHz have changed drastically sometimes to the point of being undetectable. The damage seen histologically at this time is destruction of both inner and outer hair cells. A pharmacokinetic analysis of this potentiation revealed a slight prolongation of KM's sojourn in the inner ear. The possible mechanisms of this unexpected, marked potentiation are discussed but remain unknown.
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Base de dados:
MEDLINE
Assunto principal:
Canamicina
/
Cóclea
/
Ácido Amino-Oxiacético
/
Acetatos
Limite:
Animals
Idioma:
En
Ano de publicação:
1984
Tipo de documento:
Article