Determination of minoxidil in bulk drug and pharmaceutical formulations by ion-pairing high-performance liquid chromatography.
J Pharm Sci
; 73(9): 1290-3, 1984 Sep.
Article
em En
| MEDLINE
| ID: mdl-6491953
An ion-pairing liquid chromatographic method with UV detection is described for the determination of minoxidil in bulk drug, compressed tablet, and topical solution formulations. The chromatographic system consists of a microparticulate octadecylsilica column and a mobile phase composed of sodium dioctylsulfosuccinate in aqueous methanol (pH 3). The bulk drug and the topical solution samples are prepared by the dissolution of the drug in internal standard solution. Sample preparation for the compressed tablet formulation involves dissolving the drug from an aliquot of pulverized sample and centrifuging to remove insoluble excipients. Quantitative recovery of minoxidil from formulation excipients was demonstrated; assay precision was less than 1% CV.
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Base de dados:
MEDLINE
Assunto principal:
Pirimidinas
/
Minoxidil
Idioma:
En
Ano de publicação:
1984
Tipo de documento:
Article