Response of the iron-deficient erythrocyte in the rat to hyperoxia.
J Appl Physiol Respir Environ Exerc Physiol
; 44(5): 710-7, 1978 May.
Article
em En
| MEDLINE
| ID: mdl-649473
ABSTRACT
Normal and iron-deficient rats were exposed to 90% O2 at 760 Torr for 24 or 48 h. Erythrocyte response to hyperoxia was monitored by potassium (rubidium) influx studies, by storage stress, and by ultrastructural studies. Normal rat erythrocytes exhibited morphological changes and decrease of ouabain-sensitive potassium influx compared to unexposed controls. Both components of erythrocyte potassium influx were affected by iron deficiency. Erythrocytes from unexposed iron-deficient rats showed a 50% increase in ouabain-sensitive potassium influx compared to controls. Iron-deficient rats exposed to hyperoxia for 24 or 48 h, had erythrocytes with morphological changes. Erythrocytes of iron-deficient rats exposed for 24 h showed no influx change; those exposed for 48 h showed a decrease of ouabain-sensitive influx compared to erythrocytes of controls.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Oxigênio
/
Eritrócitos
/
Anemia Hipocrômica
Limite:
Animals
Idioma:
En
Ano de publicação:
1978
Tipo de documento:
Article