A carcinogenic potency database of the standardized results of animal bioassays.
Environ Health Perspect
; 58: 9-319, 1984 Dec.
Article
em En
| MEDLINE
| ID: mdl-6525996
ABSTRACT
The preceding paper described our numerical index of carcinogenic potency, the TD50 and the statistical procedures adopted for estimating it from experimental data. This paper presents the Carcinogenic Potency Database, which includes results of about 3000 long-term, chronic experiments of 770 test compounds. Part II is a discussion of the sources of our data, the rationale for the inclusion of particular experiments and particular target sites, and the conventions adopted in summarizing the literature. Part III is a guide to the plot of results presented in Part IV. A number of appendices are provided to facilitate use of the database. The plot includes information about chronic cancer tests in mammals, such as dose and other aspects of experimental protocol, histopathology and tumor incidence, TD50 and its statistical significance, dose response, author's opinion and literature reference. The plot readily permits comparisons of carcinogenic potency and many other aspects of cancer tests; it also provides quantitative information about negative tests. The range of carcinogenic potency is over 10 million-fold.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Bioensaio
/
Sistemas de Informação
/
Carcinógenos
/
Neoplasias Experimentais
Tipo de estudo:
Qualitative_research
Limite:
Animals
Idioma:
En
Ano de publicação:
1984
Tipo de documento:
Article