Intravenous nicardipine in patients with chronic heart failure: a nuclear stethoscope study.
Postgrad Med J
; 60 Suppl 4: 35-8, 1984.
Article
em En
| MEDLINE
| ID: mdl-6527978
ABSTRACT
The effects of intravenous nicardipine (10 mg) on some aspects of left ventricular function have been studied with a radioisotope method in 10 male patients in chronic heart failure (NYHA Class II and III). Blood pressure (mean +/- s.d.) fell from 133 +/- 26/86 +/- 11 mm Hg to 103 +/- 22/69 +/- 13. Heart rate rose from 67 +/- 9 beats per minute to 85 +/- 10. Left ventricular ejection fraction rose from 31 +/- 7% to 38 +/- 6% and relative cardiac output from 24 +/- 9 to 41 +/- 11 (P less than 0.001 in all cases). This suggests that nicardipine has a potent vasodilator effect which results in increased left ventricular pumping activity in patients with mild to moderate heart failure.
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Base de dados:
MEDLINE
Assunto principal:
Bloqueadores dos Canais de Cálcio
/
Nifedipino
/
Insuficiência Cardíaca
/
Hemodinâmica
Limite:
Adult
/
Aged
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
1984
Tipo de documento:
Article