Evidence for polygenic epistatic interactions in man?
Genetics
; 106(4): 719-27, 1984 Apr.
Article
em En
| MEDLINE
| ID: mdl-6538860
ABSTRACT
Studies of multifactorial inheritance in man have ignored nonadditive gene action or attributed it entirely to dominance. Reanalyses of dermatoglyphic data on monozygotic and dizygotic twins, siblings and parents and offspring suggest that a substantial proportion of variation in total finger pattern intensity is due to epistatic interactions between additive genetic deviations, not dominance. Bootstrapping and power simulations support this interpretation of the data. We believe this is the strongest evidence so far for polygenic epistasis in man.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Dermatoglifia
/
Epistasia Genética
Limite:
Female
/
Humans
/
Pregnancy
Idioma:
En
Ano de publicação:
1984
Tipo de documento:
Article