Effects of marginal hypoxemia on recovery from oxygen-induced retinopathy in the kitten model.
Pediatrics
; 73(1): 1-6, 1984 Jan.
Article
em En
| MEDLINE
| ID: mdl-6546319
ABSTRACT
Prolonged oxygen administration in premature infants is the most predictive variable for severe retinopathy of prematurity, after degree of prematurity itself. It was noted that infants receiving prolonged oxygen supplementation are probably hypoxemic relative to their healthy counterparts. Therefore, hypoxemia during recovery from a hyperoxic-induced retinal vascular injury was tested in the kitten model of oxygen-induced retinopathy. Twelve litters were exposed to 80% inspired O2 for 65 hours on day 3, and recovered in room air, 13% or 17% oxygen. The retinas were scored at 4 weeks, and 13% oxygen recovery (PO2 = 39 +/- 18 torr) was found to worsen significantly the retinopathy compared with that in room air-recovered littermates (P less than .01). Hemorrhages occurred more frequently in the retinas from the hypoxemic-recovered kittens. Clinical trials of this hypothesis are indicated in humans.
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Base de dados:
MEDLINE
Assunto principal:
Oxigênio
/
Retinopatia da Prematuridade
/
Hipóxia
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
Limite:
Animals
/
Humans
/
Newborn
Idioma:
En
Ano de publicação:
1984
Tipo de documento:
Article