Antinuclear antibodies in Utah coal miners.
Chest
; 83(3): 515-9, 1983 Mar.
Article
em En
| MEDLINE
| ID: mdl-6600674
ABSTRACT
Antinuclear antibodies (ANA) were detected using a mouse kidney substrate in 69 of 238 (29 percent) underground Utah coal miners at a titer of 116. At titers of 14 and higher, 52 percent were positive. The majority had a speckled pattern and were not directed against any previously characterized antigens. Fifteen of 28 with high titer ANA had reduced complement. The ANA was more apt to be present in those with coal workers' pneumoconiosis (CWP), and as ANA titer increased, the percentage with CWP increased. The ANA increased with both age and coal mine dust exposure. It is hypothesized that ANA and CWP both result from long-term dust exposure, but that there is insufficient evidence to implicate ANA in the pathogenesis of CWP.
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Base de dados:
MEDLINE
Assunto principal:
Pneumoconiose
/
Anticorpos Antinucleares
/
Minas de Carvão
Tipo de estudo:
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limite:
Humans
/
Male
/
Middle aged
País como assunto:
America do norte
Idioma:
En
Ano de publicação:
1983
Tipo de documento:
Article