Responsiveness of human lung diploid fibroblast ageing in vitro to epidermal growth factor: saturation density and lifespan.

ABSTRACT

Epidermal growth factor (EGF) in culture medium increased the saturation density of human diploid fibroblasts. In the first half of their in vitro lifespan the magnitude of the EGF-induced augmentation increased and in the second half, decreased. Their lifespan was not extended by continuous exposure to EGF.